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The research contribution and interests of Yi Zhu, Ph.D., include investigating the biological function of cellular senescence under various kinds of disease conditions, particularly age-related diseases, and neurological disorders.
Senescent cells accumulate in the body with age and the onset of many diseases. Accumulation of these cells is deleterious and contributes to the development of age-related dysfunction. The goal of Dr. Zhu's research is to unravel the mechanisms of senescent cell involvement in these diseases and develop senolytic drugs to precisely target senescent cells. In 2015, Dr. Zhu discovered the first generation of senolytics, which have been validated in preclinical studies and independent research laboratories.
Senescent cells accumulate in the body with age and the onset of many diseases. Accumulation of these cells is deleterious and contributes to the development of age-related dysfunction. The goal of Dr. Zhu's research is to unravel the mechanisms of senescent cell involvement in these diseases and develop senolytic drugs to precisely target senescent cells. In 2015, Dr. Zhu discovered the first generation of senolytics, which have been validated in preclinical studies and independent research laboratories.
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PROTEOMICSno. 6 (2024): e2300242-e2300242
Journal of visualized experiments : JoVE (2024)
crossref(2024)
ESC HEART FAILUREno. 1 (2024): 524-532
Zhihong Wang, He Wang,Yan Zhou,Lu Li,Mengge Lyu, Chunlong Wu, Tianen He, Lingling Tan,Yi Zhu,Tiannan Guo,Hongkun Wu,Hao Zhang,
LIFE SCIENCE ALLIANCEno. 2 (2024)
Francis Atim Akanyibah,Yi Zhu, Aijun Wan, Dickson Kofi Wiredu Ocansey, Yuxuan Xia,An-Ning Fang,Fei Mao
International journal of molecular medicineno. 6 (2024)
Cellno. 2 (2023): 428-445.e27
SCIENCE TRANSLATIONAL MEDICINEno. 723 (2023)
Liujia Qian,Yue Gu, Qiaocheng Zhai,Zhangzhi Xue, Youqi Liu,Sainan Li,Yizhun Zeng,Rui Sun,Qiushi Zhang, Xue Cai,Weigang Ge,Zhen Dong,
MOLECULAR & CELLULAR PROTEOMICSno. 12 (2023)
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