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职业迁徙
个人简介
Ca2+ is a signaling molecule that carries information in virtually all processes important to cell life, as well as participating in cell death. My laboratory focuses on the structure-function of proteins involved in either Ca2+ homeostasis or regulating mitochondrial function in cell life and death. Understanding the biological processes regulated by Ca2+ requires identification of the proteins involved and their control mechanisms. A second major focus addresses mitochondria, the "power house" of the cell that also plays a key role in programmed cell death - apoptosis. In apoptosis, the mitochondrial protein VDAC, regulating cellular energy metabolism, serves as a site for apoptotic signaling. Since VDAC functions at a checkpoint of cell life and death and because apoptosis is rendered ineffective in cancer cells, selective induction of VDAC-mediated apoptosis in carcinogenic tissues represents a potential cancer therapy.
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M. Santhanam, S. Kumar Pandey, A. Shteinfer-Kuzmine, A. Paul, N. Abusiam, R. Zalk,V. Shoshan-Barmatz
Molecular Therapy (2024)
crossref(2023)
Apoptosisno. 5-6 (2023): 730-753
Almog Nadir,Anna Shteinfer-Kuzmine,Swaroop Kumar Pandey, Juan Ortas, Daniel Kerekes,Varda Shoshan-Barmatz
Cancersno. 5 (2023)
crossref(2023)
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