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个人简介
Dr. Tsuji’s research in the past few years has led to the identification and characterization of a unique CD4+ T cell subset, which is named “tumor-recognizing CD4+ helper T cell (TR-CD4 cell)," that directly recognizes cancer cells. Through direct recognition of cancer cells, TR-CD4 cells significantly inhibit tumor cell growth and potently enhance anti-tumor functions of cytotoxic CD8+ T cells. He also elucidated novel antigen presentation mechanisms that are involved in the presentation of intracellular tumor antigen proteins to CD4+ T cells. He recently established a method to generate large numbers of TR-CD4 cells by gene-engineering with T cell receptor (TCR) gene for the development of novel tumor adoptive T cell therapy using TR-CD4 cells.
研究兴趣
论文共 110 篇作者统计合作学者相似作者
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Bowen Dong,Nataša Obermajer,Takemasa Tsuji,Junko Matsuzaki, Cindy Bonura,Henry Withers,Mark Long,Colin Chavel,Scott H. Olejniczak, Hans Minderman,Robert P. Edwards,Walter J. Storkus,
Cancer Researchno. 6_Supplement (2024): 3966-3966
CANCER RESEARCH COMMUNICATIONSno. 11 (2023): 2256-2267
Paul Sabbatini,Takemasa Tsuji, Luis Ferran,Erika Ritter, Christine Sedrak,Kevin Tuballes,Achim A. Jungbluth,Gerd Ritter,Carol Aghajanian,Katherine M. Bell‐McGuinn,Martee L. Hensley,Jason Konner,
openalex(2023)
Hao Fan,Siyuan Xia,Junhong Xiang,Yuancheng Li, Matthew O Ross,Seon Ah Lim, Fan Yang, Jiayi Tu, Lishi Xie,Urszula Dougherty,Freya Q Zhang,Zhong Zheng,
Natureno. 7989 (2023): 1034-1043
crossref(2023)
Hemn Mohammadpour,Takemasa Tsuji,Cameron R MacDonald, Joseph L Sarow, Hanna Rosenheck,Saeed Daneshmandi,Jee Eun Choi,Jingxin Qiu,Junko Matsuzaki,Agnieszka K Witkiewicz,Kristopher Attwood,Bruce R Blazar,
Pawel Kalinski,Bowen Dong,Natasa Obermajer,Takemasa Tsuji,Junko Matsuzaki, Cindy Bonura, Henry Withers,Mark Long, Colin Chavel,Scott Olejniczak, Hans Minderman,Robert Edwards,
Research square (2023)
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A. J. Robert McGray, Jessie L. Chiello,Takemasa Tsuji,Mark Long, Kathryn Maraszek,Nicole Gaulin,Spencer R. Rosario, Suzanne M. Hess,Scott Abrams,Danuta Kozbor,Kunle Odunsi,Emese Zsiros
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 6 (2023)
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crossref(2023)
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