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个人简介
Dr. Roger Woodgate has devoted his scientific career to understanding the molecular mechanisms of damage-induced mutagenesis in prokaryotes and eukaryotes.
Research Topics
Studies on DNA Replication, Repair, and Mutagenesis in Eukaryotic and Prokaryotic Cells
Under optimal conditions, the fidelity of DNA replication is extremely high. Indeed, it is estimated that, on average, only one error occurs for every 10 billion bases replicated. However, given that living organisms are continually subjected to a variety of endogenous and exogenous DNA-damaging agents, optimal conditions rarely prevail in vivo. While all organisms have evolved elaborate repair pathways to deal with such damage, the pathways rarely operate with 100% efficiency. Thus, the persisting DNA lesions are replicated, but with much lower fidelity than in undamaged DNA. Our aim is to understand the molecular mechanisms by which mutations are introduced into damaged DNA. The process, commonly referred to as translesion DNA synthesis (TLS), is facilitated by one or more members of the Y-family of DNA polymerases that are conserved from bacteria to humans. Based on phylogenetic relationships, Y-family polymerases may be broadly classified into five subfamilies; DinB-like (polIV/pol kappa-like) proteins are ubiquitous and found in all domains of life; in contrast, the Rev1-like, Rad30A (pol eta)-like, and Rad30B (pol iota)-like polymerases are found only in eukaryotes and the UmuC (polV)-like polymerases only in prokaryotes. We continue to investigate TLS in all three domains of life: bacteria, archaea, and eukaryotes.
研究兴趣
论文共 235 篇作者统计合作学者相似作者
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Researchpp.119743-119743, (2024)
Frontiers in cellular and infection microbiology (2023): 1051602
Natalia Cestari Moreno, Dana D'Orlando,Marcela T. Latancia,Irina Bezsonova,Nicholas W. Ashton,Roger Woodgate
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2023): 90-91
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Nucleic Acids Researchno. 4 (2023): 1766-1782
Sophia Gessner, Zela Alexandria-Mae Martin,Michael A. Reiche,Joana A. Santos,Ryan Dinkele,Atondaho Ramudzuli,Neeraj Dhar,Timothy J. de Wet,Saber Anoosheh,Dirk M. Lang,Jesse Aaron,Teng-Leong Chew,
ELIFE (2023)
crossref(2023)
eLife (2023)
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