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In the mouse, the sense of smell (olfaction) is mediated by >1200 odorant receptors, the largest gene family in the genome. These receptors are G-protein coupled. Every olfactory sensory neuron in the main olfactory epithelium is thought to express only one odorant receptor gene, from one allele. Axons of neurons that express the same receptor coalesce into the same structures in the olfactory bulb, termed glomeruli, where they form synapses with second-order neurons in the olfactory pathway. It is now well established that odorant receptors are intimately involved in axonal coalescence, but the mechanisms remain obscure. Our main interests are odorant receptor gene choice, axonal wiring, and olfactory coding. Our research is done in the laboratory mouse.
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Mona Khan,Marnick Clijsters,Sumin Choi, Wout Backaert, Michiel Claerhout, Floor Couvreur, Laure Van Breda,Florence Bourgeois,Kato Speleman,Sam Klein,Johan Van Laethem,Gill Verstappen,
Mona Khan,Seung-Jun Yoo,Marnick Clijsters, Wout Backaert,Arno Vanstapel,Kato Speleman, Charlotte Lietaer,Sumin Choi,Tyler D Hether,Lukas Marcelis, Andrew Nam,Liuliu Pan,
The Lancet. Respiratory medicineno. 8 (2021): e78-e79
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