基本信息
浏览量:1
职业迁徙
个人简介
Effective immune responses against infectious agents and cancer require that immune cells traffic efficiently to the correct locations and then identify and specifically respond to threats by interacting with other cells. Lymphocytes are particularly well suited for these tasks because they can completely reorganize their cellular architecture in a matter of minutes in response to surface receptor stimulation. This remarkable structural plasticity enables them to function both rapidly and effectively in a wide variety of physiological contexts. We aim to understand the signaling mechanisms that underlie these morphological changes, which could aid in the development of strategies to better modulate immune function in vivo. We are particularly interested in:
Polarized cytoskeletal remodeling at the immunological synapse. We study how signals from activating receptors shape synaptic architecture and how inhibitory stimulation antagonizes synapse formation.
The role of cell polarity and cytoskeletal dynamics in specifying lymphocyte effector responses, with special emphasis on cytotoxic killing by T cells and natural killer (NK) cells.
Developing photochemical methods for single-cell analysis of polarized signal transduction. Our efforts focus on using localized pulses of light to stimulate cell surface receptors during imaging experiments.
Polarized cytoskeletal remodeling at the immunological synapse. We study how signals from activating receptors shape synaptic architecture and how inhibitory stimulation antagonizes synapse formation.
The role of cell polarity and cytoskeletal dynamics in specifying lymphocyte effector responses, with special emphasis on cytotoxic killing by T cells and natural killer (NK) cells.
Developing photochemical methods for single-cell analysis of polarized signal transduction. Our efforts focus on using localized pulses of light to stimulate cell surface receptors during imaging experiments.
研究兴趣
论文共 92 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Alexander H. Settle,Benjamin Y. Winer,Miguel M. de Jesus, Lauren Seeman,Zhaoquan Wang,Eric Chan,Yevgeniy Romin,Li Zhuoning, Matthew M. Miele,Ronald C. Hendrickson,Daan Vorselen,Justin S.A. Perry,
biorxiv(2024)
Stephanie Guillet,Tomi Lazarov,Natasha Jordan,Bertrand Boisson, Maria Tello,Barbara Craddock,Ting Zhou, Chihiro Nishi,Rohan Bareja, Hairu Yang,Frederic Rieux-Laucat, Rosa Irene Fregel Lorenzo,
medrxiv(2024)
NATURE IMMUNOLOGY (2023)
bioRxiv : the preprint server for biology (2023)
Benjamin Y Winer,Alexander H Settle, Alexandrina M Yakimov, Carlos Jeronimo,Tomi Lazarov, Murray Tipping, Michelle Saoi,Anjelique Sawh, Anna-Liisa L Sepp, Michael Galiano,Yung Yu Wong,Justin S A Perry,
bioRxiv : the preprint server for biology (2023)
Biophysical journalno. 3S1 (2023): 534a-534A
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn