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个人简介
My research focuses on clinical and nutritional epidemiology of cancer. Specifically, my work integrates large-scale observational studies with biomarker-based randomized clinical trials to identify novel nutritional and gut microbiota-targeted strategies for cancer prevention and treatment.
Over the past few years, I have studied the role of diet and lifestyle factors, in conjunction with host immune factors and the gut microbiota, in colorectal cancer development and survivorship. Much of my work has been based on three large prospective cohort studies, the Nurses’ Health Study I and II, and the Health Professionals Follow-up Study, in which diet, lifestyle and colorectal cancer diagnosis and mortality have been assessed over decades with blood, stool, and tumor tissue specimens collected in a subset of participants. Building on the findings from observational studies, I am leading two clinical trials of omega-3 fatty acid treatment in colon cancer patients (supported by American Cancer Society) and individuals with a history of colorectal adenoma resection (supported by NCI) at Massachusetts General Hospital to investigate causality and explore the potential for future clinical translation.
Over the past few years, I have studied the role of diet and lifestyle factors, in conjunction with host immune factors and the gut microbiota, in colorectal cancer development and survivorship. Much of my work has been based on three large prospective cohort studies, the Nurses’ Health Study I and II, and the Health Professionals Follow-up Study, in which diet, lifestyle and colorectal cancer diagnosis and mortality have been assessed over decades with blood, stool, and tumor tissue specimens collected in a subset of participants. Building on the findings from observational studies, I am leading two clinical trials of omega-3 fatty acid treatment in colon cancer patients (supported by American Cancer Society) and individuals with a history of colorectal adenoma resection (supported by NCI) at Massachusetts General Hospital to investigate causality and explore the potential for future clinical translation.
研究兴趣
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EBioMedicine (2024): 105010
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Cancer Researchno. 6_Supplement (2024): 4870-4870
Gastroenterologyno. 5 (2024): S-1084-S-1085
Gastroenterologyno. 5 (2024): S-19-S-20
Gastroenterologyno. 5 (2024): S-273-S-274
EClinicalMedicine (2024): 102572
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Gastroenterologyno. 5 (2024): S-121
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