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As neuroscience enters the post-genomic era, a major goal is the translation of genomic sequence information into a molecular understanding of the mechanisms of neuronal information processing and transfer. My laboratory’s research focuses on protein function, biochemical pathways and networks of protein-protein interactions regulating intra- and inter-cellular signaling in mammalian neurons. In particular, we are interested in dynamic regulation of voltage-sensitive ion channel abundance, localization and function through reversible protein phosphorylation. These proteins determine the intrinsic electrical properties of neurons and how these cells respond to external stimuli, integrate the encoded information and generate an appropriate response. Modern proteomic techniques have allowed for insights into protein networks, and post-translational modifications, that provide for both the generation and maintenance of complex cellular functions, but also their dynamic regulation that underlies functional plasticity. Our studies are aimed at a molecular understanding of how neuronal ion channels generate and maintain the fidelity of neuronal signaling, and how these processes can be dynamically regulated to generate neuronal plasticity. Such information is necessary for an increased understanding of not only the normal functional plasticity of neurons, but also in understanding of disease states where neuronal function is altered and effects of acute external insults such as ischemia and drugs of abuse, and represent a key step towards the development of therapeutics that can address these and other psychiatric and neurological disorders. Moreover, these studies are representative of approaches that would prove advantageous to studies on other neuronal signaling proteins. To better translate findings from genome-based studies, we have also established the UC Davis/NIH NeuroMab facility, to use information on proteins encoded in the human and other genomes to generate monoclonal antibodies for use in the research community.
研究兴趣
论文共 264 篇作者统计合作学者相似作者
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Michael Ferns,Deborah van der List, Nicholas C Vierra, Taylor Lacey,Karl Murray,Michael Kirmiz,Robert G Stewart,Jon T Sack,James S Trimmer
bioRxiv : the preprint server for biology (2024)
Nicholas C. Vierra, Luisa Ribeiro-Silva,Michael Kirmiz,Deborah van der List,Pradeep Bhandari, Olivia A. Mack,James Carroll,Elodie Le Monnier,Sue A. Aicher,Ryuichi Shigemoto,James S. Trimmer
Nature Communicationsno. 1 (2023): 5231-16
引用0浏览0WOSNATURE引用
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Kristina D. Micheva, Belvin Gong,Forrest Collman,Richard J. Weinberg, Stephen J. Smith,James S. Trimmer,Karl D. Murray
ENEUROno. 12 (2023)
British Journal of Pharmacologyno. S2 (2023): S145-S222
Nature communicationsno. 1 (2023): 4553-4553
bioRxiv : the preprint server for biology (2023)
引用3浏览0WOS引用
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Annual Review of Physiologyno. 1 (2023): 217-243
引用3浏览0引用
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Keith G Mitchell,Belvin Gong,Samuel S Hunter,Diana Burkart-Waco,Clara E Gavira-O'Neill, Kayla M Templeton,Madeline E Goethel, Malgorzata Bzymek,Leah M MacNiven,Karl D Murray,Matthew L Settles,Lutz Froenicke,
Scientific reportsno. 1 (2023): 16200-20
Keith G Mitchell,Belvin Gong,Samuel S Hunter,Diana Burkart-Waco,Clara E Gavira-O'Neill, Kayla M Templeton,Madeline E Goethel, Malgorzata Bzymek,Leah M MacNiven,Karl D Murray,Matthew L Settles,Lutz Froenicke,
bioRxiv : the preprint server for biology (2023)
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Communications Biologyno. 1 (2023): 1165-21
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