基本信息
浏览量:100
职业迁徙
个人简介
Research Interests
Human disease modelling
Cellular, genetic and biochemical analyses of RNA and protein toxicity in neurological diseases
Therapeutic intervention of neurological diseases
Representative Publications
Zhang, Q., Tsoi, H., Peng, S., Li, P.P., Lau, K.F., Rudnicki, D.D., Ngo, J.C. and Chan, H.Y.E. (2016) Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila. Dis. Model. Mech. 9, 321-34.
Nguyen, L., Luu, L.M., Peng, S., Serrano, J.F., Chan, H.Y.E. and Zimmerman, S.C. (2015) Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1. J. Am. Chem. Soc. 137, 14180-14189.
Tsoi, H., Yu, A.C., Chen, Z.S., Ng, N.K., Chan, A.Y., Yuen, L.Y., Abrigo, J.M., Tsang, S.Y., Tsui, S.K., Tong, T.M., Lo, I.F., Lam, S.T., Mok, V.C, Wong, L.K., Ngo, C.K., Lau, K.F., Chan, T.F.* and Chan, H.Y.E.* (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J. Med. Genet. 51, 590-595.
Tsoi, H. and Chan, H.Y.E.* (2013) Expression of expanded CAG transcripts triggers nucleolar stress in Huntington’s disease. Cerebellum 12, 310-312.
Lu, J.H., Tan, J.Q., Durairajan, S.S., Liu, L.F., Zhang, Z.H., Ma, L., Shen, H.M., Chan, H.Y.E.* and Li, M.* (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8, 98-108.
Tsoi, H., Lau, C.K., Tsang, S.Y., Lau, K.F. and Chan, H.Y.E.* (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc. Natl. Acad. Sci. USA. 109, 13428-13433. F1000-r1
Tsoi, H., Lau, T.C.K., Lau, K.F. and Chan, H.Y.E.* (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Hum. Mol. Genet. 20, 3787-3797.
Chan, W.M., Tsoi, H., Wu, C.C., Wong, C.H., Cheung, T.C., Li, H.Y., Lau, K.F., Shaw, P.C., Perrimon, N. and Chan, H.Y.E.* (2011) Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Hum. Mol. Genet. 20, 1738-1750.
Lee, F.K.M., Wong, A.K.Y., Lee, Y.W., Wan, O.W., Chan, H.Y.E.*, and Chung, K.K.K.* (2009) The role of ubiquitin linkages on a-synuclein induced-toxicity in a Drosophila model of Parkinson's disease. J. Neurochem. 110, 208-219. * co-corresponding author.
Wong, S.L.A., Chan, W.M., and Chan, H.Y.E.* (2008) SDS-insoluble polyglutamine oligomers are involved in neuronal degeneration. FASEB J. 22, 3348-3357.
研究兴趣
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CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGYno. 1 (2024): 30-39
NATURE COMMUNICATIONSno. 1 (2023)
Nature communicationsno. 1 (2023): 8420-19
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