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Dr. Nishikawa has studied the mechanisms by which the immunosuppressive network, including CD4+ regulatory T (Treg) cells, suppresses anti-tumor immune responses, and has also been developing therapeutic strategies to overcome these mechanisms. In particular, he found the typical phenotypes of effector T cells, which are important for anti-tumor immune responses, that are suppressed by Treg cells depending on the nature of the antigen (exhaust for non-self and anergy for self-antigens). These findings are extremely important for understanding not only tumor immunity, but also various immune responses such as autoimmunity, allergy, infection and transplantation. In addition, he has recently proposed a novel concept in the carcinogenic process in which genomic aberrations of cancer cells affect the immune response and establish an immunosuppressive network in the tumor microenvironment, and commits to develop immunogenomic precision medicine.
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论文共 334 篇作者统计合作学者相似作者
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Kosuke Tanaka, Yasuki Adachi, Miyuki Yoshiya, Takuya Owari, Tomoko Yamamori-Morita,Akihiro Ohashi,Susumu Kobayashi,Shohei Koyama,Hiroyoshi Nishikawa
Cancer Researchno. 6_Supplement (2024): 5265-5265
Nature Reviews Clinical Oncologyno. 5 (2024): 1-17
Wenhao Zhou, Shusuke Kawashima,Takamasa Ishino,Katsushige Kawase,Youki Ueda,Kazuo Yamashita,Tomofumi Watanabe,Masahito Kawazu,Hiromichi Dansako,Yutaka Suzuki,Hiroyoshi Nishikawa,Takashi Inozume,
CELL REPORTSno. 2 (2024): 113797-113797
Nina Yi-Tzu Lin,Shota Fukuoka,Daisuke Motooka,Yuko Shigeno,Takuma Irie,Dieter M. Tourlousse, Kazutoshi Murotomi,Yuji Sekiguchi,Hideyuki Tamaki,Mariko Shindo,Takahiro Tsuji, Hiroaki Wake,
Cancer Researchno. 6_Supplement (2024): 6686-6686
INTERNATIONAL IMMUNOLOGYno. 2 (2024): 75-86
Proceedings of the Japan Academy. Series B, Physical and biological sciencesno. 2 (2024): 114-122
Cancer Researchno. 6_Supplement (2024): 1211-1211
Journal for ImmunoTherapy of Cancerno. 2 (2024)
Takahiko Sato,Daisuke Sugiyama,Yasuhiro Kojima, Satomi Hattori, Kazuki Sone, Tomohiro Ishikawa,Yuichi Ishikawa, Takuma Kato,Hitoshi Kiyoi,Hiroyoshi Nishikawa
Cancer Researchno. 6_Supplement (2024): 2671-2671
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 2 (2024)
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