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Molecular Biology of the Insulin-Like Growth Factor System
The insulin-like growth factors (IGF1, IGF2) are a family of hormones with important roles in growth and development. The biological actions of the IGFs are mediated by the IGF1 receptor (IGF1R), a cell-surface receptor related to the insulin receptor. The IGF1R signaling pathway has an important role in the biochemical chain of events linking obesity, diabetes, and cancer. Our work is aimed at understanding the molecular and cellular events responsible for IGF1R expression in cancer. These studies are expected to generate information that might translate into more efficient IGF1R targeting approaches. Furthermore, a better understanding of the molecular biology of the IGF system will have important ramifications in areas such as obesity, metabolic syndrome, diabetes, and cancer research. Specific topics include:
Interplay between the IGF signaling pathways and cancer genes (p53, BRCA).
IGF1R targeting as a therapeutic approach in cancer.
Epigenetic mechanisms in cancer development.
Biological activities of insulin analogues.
Metabolism and cancer.
Molecular Biology of the Insulin-Like Growth Factor System
The insulin-like growth factors (IGF1, IGF2) are a family of hormones with important roles in growth and development. The biological actions of the IGFs are mediated by the IGF1 receptor (IGF1R), a cell-surface receptor related to the insulin receptor. The IGF1R signaling pathway has an important role in the biochemical chain of events linking obesity, diabetes, and cancer. Our work is aimed at understanding the molecular and cellular events responsible for IGF1R expression in cancer. These studies are expected to generate information that might translate into more efficient IGF1R targeting approaches. Furthermore, a better understanding of the molecular biology of the IGF system will have important ramifications in areas such as obesity, metabolic syndrome, diabetes, and cancer research. Specific topics include:
Interplay between the IGF signaling pathways and cancer genes (p53, BRCA).
IGF1R targeting as a therapeutic approach in cancer.
Epigenetic mechanisms in cancer development.
Biological activities of insulin analogues.
Metabolism and cancer.
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Frontiers in Endocrinology (2023): 1291812-1291812
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Medical research archivesno. 4 (2023)
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Endocrine-related cancerno. 9 (2023)
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 19 (2023): 14882-14882
Hala Khazem,Dvir Reder, Shilhav Meisel Sharon,Shay Hantisteanu,Hallak Mordechai,Haim Werner,Ilan Bruchim
E-Posters (2022)
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