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Baruch’s research did not stop with the cloning of the transporters, the cloning just gave him the tools to continue with his passion, i.e. to figure out how these transporters work. In consequence, a large number of papers were published with diligent structure function analysis of GABA and glutamate transporter. His publications are too numerous to discuss, with a total number of 139 papers, showcasing a very prolific career. However, two additional major contributions should be highlighted: (1) The identification of the chloride binding site of the GABA transporter, published in Nature in 2007. This breakthrough was possible because of Baruch's keen eye in identifying minor differences in sequences of GAT1 (SLC6) family members, which, in combination with careful site-directed mutagenesis approaches allowed the prediction of this important binding site. (2) The discovery of the inverted repeat structural fold of glutamate transporters, in collaboration with Lucy Forrest, which led to the prediction of an inward facing structure of the transporter. This structure was soon after confirmed by x-ray crystallography with GltPh.
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Erika Lazzarin,Ralph Gradisch, Sophie MC Skopec,Leticia Alves da Silva, Chiara Sebastianelli-Schoditsch,Daniel Szollosi,Julian Maier,Sonja Sucic, Marko Roblek,Baruch Kanner,Harald H Sitte,Thomas Stockner
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Smruti Ranjan Nayak,Deepthi Joseph,Georg Höfner,Archishman Dakua,Arunabh Athreya,Klaus T. Wanner,Baruch I. Kanner,Aravind Penmatsa
Nature structural & molecular biologyno. 7 (2023): 1023-1032
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