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Research Abstract
Mosquitoes are arguably the most dangerous animals in the world. Annual human mortality from malaria transmitted by just one species, Anopheles gambiae, exceeds two million, while Aedes aegypti transmits viral diseases such as dengue and yellow fever. While these diseases occur principally in tropical zones, emerging pathogens such as Chikungunya and West Nile viruses may represent future medical and public health threats in more temperate regions. The goal of our laboratory is to develop novel, genetics-based control methods for blocking transmission of human pathogens by mosquitoes. The hypothesis driving our efforts is that the introduction into a population of mosquitoes of a gene that confers resistance to a pathogen should lead to a decrease in transmission of that pathogen. Implicit in this hypothesis is the assumption that less transmission will result in less disease and death. To test this hypothesis, a gene or allele that interferes with pathogen development or propagation must be discovered or developed, and subsequently spread through a mosquito population. Following implementation of this strategy, there should be measurable decreases in incidence and prevalence of the targeted disease.
Mosquitoes are arguably the most dangerous animals in the world. Annual human mortality from malaria transmitted by just one species, Anopheles gambiae, exceeds two million, while Aedes aegypti transmits viral diseases such as dengue and yellow fever. While these diseases occur principally in tropical zones, emerging pathogens such as Chikungunya and West Nile viruses may represent future medical and public health threats in more temperate regions. The goal of our laboratory is to develop novel, genetics-based control methods for blocking transmission of human pathogens by mosquitoes. The hypothesis driving our efforts is that the introduction into a population of mosquitoes of a gene that confers resistance to a pathogen should lead to a decrease in transmission of that pathogen. Implicit in this hypothesis is the assumption that less transmission will result in less disease and death. To test this hypothesis, a gene or allele that interferes with pathogen development or propagation must be discovered or developed, and subsequently spread through a mosquito population. Following implementation of this strategy, there should be measurable decreases in incidence and prevalence of the targeted disease.
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论文共 321 篇作者统计合作学者相似作者
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Xiaolin Xiao,Ling Kong,Zhensheng Xie,Hongkai Liu, Lijun Cai,Siyu Zhao,Jiayong Zhou,Shuang Liu,Jing Wu, Yiming Wu, Peilin Wu,Anthony A. James,
INSECT SCIENCE (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 33 (2023)
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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023): 1261123-1261123
Proceedings of the National Academy of Sciences of the United States of Americano. 29 (2023)
Frontiers in cellular and infection microbiology (2023): 1132647-1132647
Proceedings of the National Academy of Sciences of the United States of Americano. 33 (2023)
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Vanessa Bottino-Rojas,Anthony A James
Cold Spring Harbor protocols (2023)
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