Integration of the Molecular Classification of Endometrial Carcinoma to Select Patients for Fertility Sparing Strategies

Fertility-sparing treatment (FST) for endometrial
carcinoma (EC) is an option for a subgroup of young women
with low-risk disease. The low-risk group comprises patients
with endometrioid EC stage IA, grade 1, with or without focal
lymphovascular invasion. In the era of molecular subtyping,
treatment de-escalation for some EC subtypes is recommended.
Recommendations for fertility-preserving treatments were
developed regardless of the molecular classification of EC.
However, few studies have focused on this topic. In this review,
we summarize the actual data available in the literature and
discuss the impact of some molecular subtypes of FST