High-strength and ultra-tough spun from transgenic silkworms

To advance ecological civilization, developing sustainable, eco-friendly high-strength and ultra-tough alternatives to non -sustain-able synthetic fibers, such as nylon, is crucial. This necessitates a deeply scientific understanding of the fundamental determinants of fiber strength and toughness, as well as overcoming engineering challenges for cost-effective, large-scale production of high-performance silk fibers. Inspired by the mechanical properties of polyamide fibers, including nylon and Kevlar, we employed CRISPR-Cas9-mediated gene editing to successfully synthesize whole polyamide spider silk fibers from transgenic silkworms. These fibers exhibited impressive tensile strength (1,299 MPa) and tough-ness (319 MJ/m3), surpassing Kevlar's toughness 6-fold. Thus, they offer promising potential as sustainable alternatives to synthetic commercial fibers. Furthermore, our research provides valuable in-sights into the fundamental essence of fiber toughness and tensile strength, challenging the conventional notion that these properties are contradictory. These findings have significant implications for guiding the production of synthetic commercial fibers that simultaneously possess high strength and ultra-toughness.