A single center case series of immune checkpoint inhibitor-induced type 1 diabetes mellitus, patterns of disease onset and long-term clinical outcome.

John Marsiglio,Jordan P McPherson,Magdalena Kovacsovics-Bankowski,Joanne Jeter,Christos Vaklavas,Umang Swami, Douglas Grossmann, Alyssa Erickson-Wayman,Heloisa P Soares,Katie Kerrigan,Berit Gibson,Jennifer Anne Doherty,John Hyngstrom,Sheetal Hardikar,Siwen Hu-Lieskovan

Frontiers in immunology（2023）

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摘要

Our case series demonstrates rapid onset and irreversibility of ICI-induced T1DM. Melanoma patients with ICI-induced T1DM display excellent clinical response and survival. Limited proteomic data also suggested a unique proteomic profile. Our study helps clinicians to understand the unique clinical presentation and long-term outcomes of this rare irAE for best clinical management.

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关键词

diabetes mellitus,disease onset,immune,inhibitor-induced,long-term

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