Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α) 8 barrel enzymes

Gregory C Patton,Pål Stenmark,Deviprasad R Gollapalli,Robin Sevastik,Petri Kursula,Susanne Flodin,Herwig Schuler,Colin T Swales,Hans Eklund,Fahmi Himo,Pär Nordlund,Lizbeth Hedstrom

Nature Chemical Biology（2011）

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摘要

IMPDH and GMPR have similar active sites, but their reactions cause opposite effects on the guanine nucleotide pool. Biochemical and crystallographic evidence point to cofactor conformation as distinguishing the two reaction mechanisms and demonstrate that GMPR can substitute for IMPDH, prompting further investigations of this metabolic cycle.

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