Effects of transcription factor ChREBP on NAFLD-driven Hepatocarcinogenesis

Background and Aims The transcription factor carbohydrate response element binding protein (ChREBP) is involved in the modulation of glycolytic and lipogenic pathways [1]. Dysregulation of lipogenesis facilitates the development of non-alcoholic fatty liver disease (NAFLD) [2]. Previous studies have suggested that ChREBP is associated to development of hepatocellular carcinoma (HCC) [3]. However, the molecular pathogenesis of ChREBP-related hepatocarcinogesis in response to the prolonged high fat diet (HFD) feeding in the mouse model remains unexplored.