Mp08-08 en bloc resection versus conventional turbt for t1hg bladder cancer: a propensity score-matched analysis

You have accessJournal of UrologyCME1 Apr 2023MP08-08 EN BLOC RESECTION VERSUS CONVENTIONAL TURBT FOR T1HG BLADDER CANCER: A PROPENSITY SCORE-MATCHED ANALYSIS Takafumi Yanagisawa, Akihiro Matsukawa, Kosuke Iwatani, Shun Sato, Yasushi Hayashida, Yohei Okada, Takashi Yorozu, Wataru Fukuokaya, Keigo Sakanaka, Fumihiko Urabe, Shoji Kimura, Shunsuke Tsuzuki, Jun Miki, Masayuki Shimoda, Hiroyuki Takahashi, Shahrokh F. Shariat, and Takahiro Kimura Takafumi YanagisawaTakafumi Yanagisawa More articles by this author , Akihiro MatsukawaAkihiro Matsukawa More articles by this author , Kosuke IwataniKosuke Iwatani More articles by this author , Shun SatoShun Sato More articles by this author , Yasushi HayashidaYasushi Hayashida More articles by this author , Yohei OkadaYohei Okada More articles by this author , Takashi YorozuTakashi Yorozu More articles by this author , Wataru FukuokayaWataru Fukuokaya More articles by this author , Keigo SakanakaKeigo Sakanaka More articles by this author , Fumihiko UrabeFumihiko Urabe More articles by this author , Shoji KimuraShoji Kimura More articles by this author , Shunsuke TsuzukiShunsuke Tsuzuki More articles by this author , Jun MikiJun Miki More articles by this author , Masayuki ShimodaMasayuki Shimoda More articles by this author , Hiroyuki TakahashiHiroyuki Takahashi More articles by this author , Shahrokh F. ShariatShahrokh F. Shariat More articles by this author , and Takahiro KimuraTakahiro Kimura More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003223.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The potential benefits of en bloc resection of bladder tumor (ERBT) compared to cTURBT have not been well verified, specifically for pT1 bladder cancer. We aimed to assess the clinical, oncological, and pathological impact of en bloc resection of bladder tumors (ERBT) compared to conventional transurethral resection of bladder tumors (cTURBT) for pT1 high grade (HG) bladder cancer. METHODS: We retrospectively analyzed the record of 326 patients (cTURBT: n=216, ERBT: n=110) diagnosed with pT1 HG bladder cancer at multiple institutions. The cohorts were matched by one-to-one propensity scores based on patient and tumor demographics. Recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS), perioperative and pathologic outcomes were compared. The prognosticators of RFS and PFS were analyzed using the Cox proportional hazard model. RESULTS: After matching, 202 patients (cTURBT: n=101, ERBT: n=101) were retained. There were no differences in perioperative outcomes between the two procedures. The 3-year RFS, PFS as well as CSS were not different between the two procedures (p=0.7, 1, 0.7, respectively). Among patients who underwent repeat transurethral resection (reTUR), the rate of any residue on reTUR were significantly lower in the ERBT group (cTURBT: 36% vs. ERBT: 15%, p=0.029). Adequate sampling of muscularis propria (83% vs. 93%, p=0.029), diagnostic rates of pT1a/b substaging (90% vs. 100%, p<0.001) were significantly better in ERBT specimen compared to cTURBT specimen. In multivariable analyses, pT1a/b substaging was a prognosticator of disease progression. CONCLUSIONS: In pT1HG bladder cancer patients, ERBT had similar perioperative and mid-term oncologic outcomes compared to cTURBT. However, ERBT improves the quality of resection and specimen, yielding less residue on reTUR and superior histopathologic information such as substaging. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e96 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takafumi Yanagisawa More articles by this author Akihiro Matsukawa More articles by this author Kosuke Iwatani More articles by this author Shun Sato More articles by this author Yasushi Hayashida More articles by this author Yohei Okada More articles by this author Takashi Yorozu More articles by this author Wataru Fukuokaya More articles by this author Keigo Sakanaka More articles by this author Fumihiko Urabe More articles by this author Shoji Kimura More articles by this author Shunsuke Tsuzuki More articles by this author Jun Miki More articles by this author Masayuki Shimoda More articles by this author Hiroyuki Takahashi More articles by this author Shahrokh F. Shariat More articles by this author Takahiro Kimura More articles by this author Expand All Advertisement PDF downloadLoading ...