High-Grade Serous Carcinoma at Risk-Reducing Salpingo-Oophorectomy in Asymptomatic Carriers of BRCA1/2 Pathogenic Variants: Prevalence and Clinical Factors.

Iris A S Stroot,Jan Brouwer,Joost Bart,Harry Hollema,Denise J Stommel-Jenner, Marise M Wagner,Helena C van Doorn,Joanne A de Hullu,Katja N Gaarenstroom, Marc Beurden,Luc R C W van Lonkhuijzen,Brigitte F M Slangen,Ronald P Zweemer,Encarna B Gómez Garcia,Margreet G E M Ausems,Ingrid A Boere,Klaartje van Engelen,Christi J van Asperen,Marjanka K Schmidt,Marijke R Wevers,Geertruida H de Bock,Marian J E Mourits

Journal of clinical oncology : official journal of the American Society of Clinical Oncology（2023）

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摘要

We detected HGSC in 1.5% (-PV) and 0.6% (-PV) of RRSO specimens from asymptomatic -PV carriers. Consistent with the fallopian tube hypothesis, we found most lesions in the fallopian tube. Our results highlight the importance of timely RRSO with total removal and assessment of the fallopian tubes and show the protective effects of long-term OCP.

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