A Retrospective, Single-Institution Experience of Bullous Pemphigoid as an Adverse Effect of Immune Checkpoint Inhibitors

Simple Summary This article investigates the cutaneous adverse immune effects induced by immune checkpoint inhibitors. These drugs target proteins expressed on cancer cells that aid in the avoidance of immune system detection and destruction. Immune checkpoint inhibitors inadvertently cause other immune-mediated adverse effects. Cutaneous toxicities are the commonest adverse effect from immunotherapy; furthermore, they are usually developed early in the course of treatment. A rare and severe cutaneous adverse event is Bullous Pemphigoid. This article investigates the average and median onset of these drug toxicities, as well as treatments. We found these side effects to be negatively skewed, indicating most cases occur several months into treatment. Immune checkpoint inhibitors are a class of cancer treatment drugs that stimulate the immune system's ability to fight tumor cells. These drugs are monoclonal antibodies targeting im-mune-inhibiting proteins on cancer cells, such as CTLA-4 and PD-1/PD-L1. Immune checkpoint inhibitors cause many immune-related adverse events. Cutaneous toxicities are of the most common adverse effects and occur with a range of severity. Bullous Pemphigoid is a rare adverse event with a high impact on quality of life that may occur after immune checkpoint inhibitor treatment. In this article, we investigate current research on immune checkpoint inhibitors, cutaneous adverse events, and common presentations and treatments, with a specific focus on Bullous Pemphigoid, its characteristics, onset timing, and treatment. Significant findings include a negative skew in the onset of presentation. Furthermore, we describe exclusive cases.