Isoflurane has no effect on cognitive or behavioral performance in a mouse model of early-stage Alzheimer's disease.

Laura Borgstedt,Sebastian Bratke,Manfred Blobner, Christoph Pötzl,Bernhard Ulm,Bettina Jungwirth,Sebastian Schmid

Frontiers in neuroscience（2022）

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摘要

We found that 10 months old Tg2576 showed typical signs of early-stage Alzheimer's disease and corresponding histopathological alterations. Relevant sex-specific differences or an effect of isoflurane anesthesia could not be detected at this early stage of the disease.

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关键词

Alzheimer’s disease,anesthesia,cognitive impairment,modified hole board test,sex-specific differences,transgenic mice

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