Risk of endometrial cancer in asymptomatic postmenopausal women in relation to ultrasonographic endometrial thickness.

We read with interest the review by Vitale et al.1 The implication of this review is that the most important parameter in assessing the risk of endometrial cancer, which should lead to initiating invasive diagnostic procedures, is the endometrial thickness (ET), whether the cutoff may be 3 or 6 mm. The authors accept that there is no guideline for universal screening for endometrial cancer but imply that incidental screening at routine gynecologic examinations should be performed. In the author’s meticulous statistical analysis of ET, they failed to include other risk factors, such as age, obesity, hormonal treatments, or family history.