Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock

•Different patterns of clock genes expression were found between normal and osteoarthritic cartilage.•Circadian rhythm disturbance reduced amplitudes of Per2 in chondrocytes.•DMOG remodeled circadian gene expression and was an agonist in the circadian oscillator in a HIF1α-dependent manner.•HBS regions are essential for HIF1α-dependent regulation of Per2 transcription.•Application of DMOG mitigated the increased OA severity caused by jet lag in DMM model.