B7-H3 as a Therapeutic Target in Advanced Prostate Cancer

European Urology（2023）

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摘要

B7-H3 is overexpressed by the majority of advanced prostate cancers, with its expression associating with alterations of DNA damage repair genes, such as BRCA2 and ATM, but not MMR protein loss. B7-H3 expression is a therapeutic vulnerability for a B7-H3–targeting antibody-drug conjugate with a topoisomerase-1 payload.

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关键词

B7-H3,Prostate cancer,Adenocarcinoma,Neuroendocrine,DNA damage repair,Antibody drug conjugate

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