Effect of macrophage migration inhibitory factor on pulmonary vein arrhythmogenesis through late sodium current.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology（2023）
摘要
Macrophage migration inhibitory factor increased PV arrhythmogenesis through Na+ and Ca2+ dysregulation through the ROS activation of CaMKII signalling, which may contribute to the genesis of AF during inflammation. Anti-CaMKII treatment may reverse PV arrhythmogenesis. Our results clearly reveal a key link between MIF and AF and offer a viable therapeutic target for AF treatment.
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关键词
Atrial fibrillation,Calcium/calmodulin kinase II,Late sodium current,Macrophage migration inhibitory factor,Pulmonary vein
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