Predicting Survival for Chimeric Antigen Receptor T-Cell Therapy: A Validation of Survival Models Using Follow-Up Data From ZUMA-1

Value in Health(2022)

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摘要
•Cure-based models were able to produce consistent and accurate extrapolations of longer-term survival for patients treated with axicabtagene ciloleucel, even with limited follow-up data.•Models without a cure fraction may provide reasonable fits to the Kaplan-Meier estimate but did not seem to extrapolate well in our study, particularly standard parametric models.•Cure-based models provide a useful tool to allow for the estimation of plausible survival extrapolations based on limited follow-up data and inform timely and accurate decision making.
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关键词
chimeric antigen receptor T-cell,mixture-cure model,non-Hodgkin lymphoma,survival extrapolation
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