Supramolecular organization and biological interaction of squalenoyl siRNA nanoparticles

Marie Caillaud,Frédéric Gobeaux,Miryana Hémadi,Suzan Boutary,Patrick Guenoun,Didier Desmaële,Patrick Couvreur,Frank Wien,Fabienne Testard,Liliane Massaad-Massade

International Journal of Pharmaceutics（2021）

引用 3|浏览24

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摘要

•- siRNA-squalene (SQ) nanoparticles (NPs) are efficient in vivo.•- siRNA-SQ self-assembled as 11-nm diameter core/shell supramolecular assemblies.•- siRNA-SQ form spherical nanoparticles of around 130-nm diameter.•- siRNA-SQ NPs were stable in biological media and interacted with albumin and LDL.

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关键词

siRNA,Nanotechnologies,Structural studies,Biological interaction,Azido-Squalene (N3-SQ),cationic squalenaldehyde hydrazinoguanidinium acetate salt (SQ+),dibenzylcyclooctyne (DBCO),N-(hexamethylenyl)-6-oxohexanamide spacer (C6),Bovine serum albumin (BSA),Low density lipoprotein (LDL),Lipofectamine 3:1 DOSPA (2,3‐dioleoyloxy‐N‐ [2(sperminecarboxamido)ethyl]‐N,N‐dimethyl‐1‐propaniminium trifluoroacetate) : DOPE (1,2-dioleoyl-sn-glycéro-3-phosphoethanolamine),Sybr Green C32H37N4S

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