Identification of SkpA-CulA-F-box E3 ligase complexes in pathogenic Aspergilli.

•Skp1/Cul1/F-box (SCF) complexes regulate protein degradation in eukaryotes.•fbx-encoding genes have been identified in Aspergillus flavus and A. fumigatus.•SkpA interacts with F-box proteins to form SCF complexes in Aspergillus species.•SCF complex conformations vary in response to different exogenous stresses.•In both species, Fbx45 interacts with SkpA in the presence of Amphotericin B.