A novel neuronal organoid model mimicking glioblastoma (GBM) features from induced pluripotent stem cells (iPSC).

Jin Wook Hwang,Julien Loisel-Duwattez,Christophe Desterke,Theodoros Latsis,Sarah Pagliaro,Frank Griscelli,Annelise Bennaceur-Griscelli,Ali G Turhan

Biochimica et Biophysica Acta (BBA) - General Subjects（2020）

引用 16|浏览15

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摘要

•c-met overexpression is one of the features of GBM with aggressive behavior and poor prognosis.•We report here that c-met-mutated iPSC allows generation of neuronal-like organoids mimicking GBM.•This c-met mutated iPSC derived model can be a novel resource for GBM research in future studies.

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关键词

C-met (hepatocyte growth factor receptor),Human induced pluripotent stem cells,Long-term aggregate culture,Organoid,Glioblastoma (GBM)

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