Analysis Of Hereditary Cancer Syndromes In Patients From The United Arab Emirates.

e13509Background: Hereditary cancer accounts for approximately 10% of all cancers. An estimated 15-20% of all cancer patients have positive family history. However, until recently mutations in highly penetrant genes were only identified in approximately 20% of high-risk families. Technological advances in DNA sequencing, commonly designated as “Next Generation Sequencing-NGS” allowed to identify new genes responsible for the missing heritability, allowing the application of this knowledge in the diagnostic setting. Methods: Between 2015 and 2017, 276 patients were tested at two institutions in Dubai, UAE for BRCA1 and BRCA2 genes and the common CHEK2 c.1100delC mutation. In 2017, testing was extended to include 33 genes for 89 patients tested. Testing for all 276 patients was conducted at a single laboratory with testing criteria based on NCCN guidelines. Results: At the time of testing, median age was 44 years (range 26–72 years) with the majority of patients diagnosed with breast cancer. Patients tested...