Glucagon-like peptide-1 regulates calcium homeostasis and electrophysiological activities of HL-1 cardiomyocytes.

Jen Hung Huang,Yao Chang Chen,Ting I. Lee,Yu Hsun Kao, Tze Fan Chazo,Shih Ann Chen,Yi Jen Chen

Peptides（2016）

引用 23|浏览7

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摘要

•GLP-1 changes calcium homeostasis with an increase of SR calcium contents.•Downregulation of phospholamban may increase SERCA2a activity.•Decreases of phosphorylated RyR2 S2814 may modulate the arrhythmogenetic activity.

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关键词

Atrial arrhythmogenesis,Calcium handling protein,Glucagon like-peptide-1,Ryanodine receptor

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