Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2.

Sara Knowles,Sarah Budney,Malavika Deodhar,Stephanie A Matthews,Kristina A Simeone,Timothy A Simeone

Epilepsy Research（2018）

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摘要

•The ketogenic diet increases hippocampal catalase mRNA and protein.•The ketogenic diet does not increase catalase mRNA or protein in the hippocampus of mice lacking PPARγ2.•Inhibiting catalase occluded the KD antiseizure effects.

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关键词

Epilepsy,In vivo,PPAR,PPARgamma,Peroxisome proliferator activated receptor,Metabolism

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