基本信息
浏览量:3
职业迁徙
个人简介
Airway remodelling in asthma is categorised by airway smooth muscle hypertrophy and hyperplasia, change in the type and amount of the extra cellular matrix and epithelial shedding and mucous gland hyperplasia. Our interest is how airway proteases and myofibroblast / extra cellular matrix interactions effect myofibroblast growth and behaviour. These studies employ primary airway cell culture, co-cultures, protein expression, functional activity assay real time PCR and proteomics.
Lymphangioleiomyomatosis (LAM) is a rare lung and lymphatic disease categorised by infiltration of smooth muscle type cells in the lungs and lymphatics leading to progressive respiratory impairment. The disease only effects women and is caused by a defect in one of the two proteins associated with tuberous sclerosis, tuberin and hamartin. Our group has a clinical interest in LAM, runs the UK LAM database and is involved in a number of clinical studies and trials.
Laboratory research projects on LAM include the mechanisms of lung destruction in LAM, prognostic biomarkers and the generation of model systems to study LAM.
Matrix metalloproteinases are proteolytic enzymes secreted by a range of cells and regulated by pro-inflammatory cytokines, growth factors, and extra cellular matrix. We have been studying these in airway myofibroblasts and also specific diseases including chronic obstructive pulmonary disease and LAM.
Lymphangioleiomyomatosis (LAM) is a rare lung and lymphatic disease categorised by infiltration of smooth muscle type cells in the lungs and lymphatics leading to progressive respiratory impairment. The disease only effects women and is caused by a defect in one of the two proteins associated with tuberous sclerosis, tuberin and hamartin. Our group has a clinical interest in LAM, runs the UK LAM database and is involved in a number of clinical studies and trials.
Laboratory research projects on LAM include the mechanisms of lung destruction in LAM, prognostic biomarkers and the generation of model systems to study LAM.
Matrix metalloproteinases are proteolytic enzymes secreted by a range of cells and regulated by pro-inflammatory cytokines, growth factors, and extra cellular matrix. We have been studying these in airway myofibroblasts and also specific diseases including chronic obstructive pulmonary disease and LAM.
研究兴趣
论文共 225 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
D Clements,R Babaei-Jadidi, J Johnson,S Miller, N Shah, JMB Sand,DJ Leeming,LA Borthwick,AJ Fisher,A Dufour,SR Johnson
biorxiv(2024)
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINEno. 4 (2024): 358-359
Orphanet Journal of Rare Diseasesno. 1 (2024): 1-8
Dapeng Wang, Niran Hadad,Samuel Moss, Elena Lopez-Jimenez,Simon R. Johnson, Toby M Maher,Philip L Molyneaux, Yajie Zhao,John R. B. Perry, Paul J. Wolters,Jonathan A. Kropski, R Gisli Jenkins,
crossref(2024)
THORAXno. 4 (2024): 366-377
Muhunthan Thillai,Justin M Oldham,Alessandro Ruggiero, Fahdi Kanavati,Tom McLellan,Gauri Saini,Simon R Johnson,Francois-Xavier Ble, Adnan Azim,Kristoffer Ostridge,Adam Platt,Maria Belvisi,
American journal of respiratory and critical care medicine (2024)
Allison R Hanaford,Asheema Khanna,Katerina James,Yihan Chen,Michael Mulholland, Bernhard Kayser,Vivian Truong, Margaret Sedensky,Phil Morgan,Vandana Kalia, Nathan Baerchst, Surojit Sarkar,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Annals of the American Thoracic Societyno. 9 (2023): 1267-1273
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn